Sterility assessment of multiple use botulinum A exotoxin vials: a prospective simulation.

@article{Alam2006SterilityAO,
  title={Sterility assessment of multiple use botulinum A exotoxin vials: a prospective simulation.},
  author={M Alam and Simon S Yoo and David A Wrone and Lucile E White and John Y. Kim},
  journal={Journal of the American Academy of Dermatology},
  year={2006},
  volume={55 2},
  pages={272-5}
}
BACKGROUND A preponderance of evidence now indicates that storage of reconstituted botulinum toxin solution for longer than the 4 hours recommended by the manufacturer does not result in loss of effectiveness. OBJECTIVE Then purpose of this study was to assess whether serial re-extraction of reconstituted botulinum toxin solution from vials undergoing prolonged storage is associated with increased risk of microbial contamination. METHODS Consecutive 100-U vials of botulinun A exotoxin were… CONTINUE READING

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