Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro.

@article{Kirpotin1997StericallySA,
  title={Sterically stabilized anti-HER2 immunoliposomes: design and targeting to human breast cancer cells in vitro.},
  author={Dmitri B. Kirpotin and Junguk Park and Keelung Hong and Samuel Zalipsky and Wen Li Li and Paul H Carter and Christopher C. Benz and Demetrios Papahadjopoulos},
  journal={Biochemistry},
  year={1997},
  volume={36 1},
  pages={66-75}
}
Liposomes (70-100 nm) of 1-palmitoyl-2-oleoylphosphatidylcholine, cholesterol, and poly(ethylene glycol) (PEG)-modified phosphatidylethanolamine (PEG-DSPE) were conjugated to Fab' fragments of a humanized recombinant MAb against the extracellular domain of HER2/neu to create sterically stabilized immunoliposomes (anti-HER2 SL) as a drug carrier targeting HER2-overexpressing cancers. Conjugation employed maleimide-terminated membrane-anchored spacers of two kinds: a short spacer, providing… CONTINUE READING
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