Steric hindrance effects on surface reactions: applications to BIAcore

@article{Edwards2007StericHE,
  title={Steric hindrance effects on surface reactions: applications to BIAcore},
  author={D. A. Edwards},
  journal={Journal of Mathematical Biology},
  year={2007},
  volume={55},
  pages={517-539}
}
Because surface-volume reactions occur in many biological and industrial processes, understanding the rate of such reactions is important. The BIAcore surface plasmon resonance (SPR) biosensor for measuring rate constants has such a geometry. Though several models of the BIAcore have been presented, few take into account that large ligand molecules can block multiple receptor sites, thus skewing the sensogram data. In this paper some general mathematical principles are stated for handling this… CONTINUE READING

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