Corpus ID: 19486603

Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis.

  title={Steric effects at C-20 and C-24 on the metabolism of sterols by Tetrahymena pyriformis.},
  author={W. Nes and J. M. Joseph and J. R. Landrey and S. Behzadan and R. Conner},
  journal={Journal of lipid research},
  volume={22 5},
  • W. Nes, J. M. Joseph, +2 authors R. Conner
  • Published 1981
  • Chemistry, Medicine
  • Journal of lipid research
  • Cultures of Tetrahymena pyriformis were incubated with various sterols and the extent of dehydrogenation at C-7 and C-22 was determined. The sterols incubated were desmosterol, 22-dehydrodesmosterol, 24-methyldesmosterol, 24 alpha-methylcholesterol (campesterol), 24-methylene-cholesterol, isohalosterol (26,27-bisnorcampesterol, also known as 24,24-dimethylchol-5-en-e beta-ol, a naturally occurring C26-sterol), and 20-isohalosterol. 20-Isohalosterol was not metabolized, while products with delta… CONTINUE READING
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