Steric constraints in the recognition of peptide substrates for the epidermal growth factor receptor kinase.

@article{Tong1996StericCI,
  title={Steric constraints in the recognition of peptide substrates for the epidermal growth factor receptor kinase.},
  author={K Tong and Cheryl A Guyer and James V. Staros},
  journal={International journal of peptide and protein research},
  year={1996},
  volume={47 3},
  pages={219-26}
}
Epidermal growth factor (EGF) stimulates cellular mitogenesis by binding to and activating its membrane-associated receptor. An important component of signal transduction by the activated receptor is the stimulation of an intrinsic tyrosyl residue-specific protein kinase, which selectively phosphorylates tyrosyl residues in the cytoplasmic tail of the… CONTINUE READING