Steric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins

@inproceedings{Bhagatji2009StericAN,
  title={Steric and not structure-specific factors dictate the endocytic mechanism of glycosylphosphatidylinositol-anchored proteins},
  author={Pinkesh Bhagatji and Rania Leventis and Jonathan W D Comeau and Mohammad Refaei and John R Silvius},
  booktitle={The Journal of cell biology},
  year={2009}
}
Diverse glycosylphosphatidylinositol (GPI)-anchored proteins enter mammalian cells via the clathrin- and dynamin-independent, Arf1-regulated GPI-enriched early endosomal compartment/clathrin-independent carrier endocytic pathway. To characterize the determinants of GPI protein targeting to this pathway, we have used fluorescence microscopic analyses to compare the internalization of artificial lipid-anchored proteins, endogenous membrane proteins, and membrane lipid markers in Chinese hamster… CONTINUE READING

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