Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.

@article{Agathangelidis2012StereotypedBR,
  title={Stereotyped B-cell receptors in one-third of chronic lymphocytic leukemia: a molecular classification with implications for targeted therapies.},
  author={Andreas Agathangelidis and Nikos Darzentas and Anastasia Hadzidimitriou and Xavier Brochet and Fiona R. Murray and Xiao J Yan and Zadie A Davis and Ellen J van Gastel-Mol and Cristina Tresoldi and Charles C Chu and Nicola Cahill and V{\'e}ronique Giudicelli and Boris Tichy and Lone Bredo Pedersen and Letizia Foroni and Lisa Bonello and Agnieszka Janus and Karin E Smedby and Achilles Anagnostopoulos and H{\'e}l{\`e}ne Merle-B{\'e}ral and N. Laoutaris and Gunnar Juliusson and Paola Francia di Celle and Sarka Pospisilova and Jesper Jurlander and Christian Hartman Geisler and Athanasios S. Tsaftaris and Marie-Paule Lefranc and Anton W. Langerak and David Oscier and Nicholas Chiorazzi and Chrysoula J Belessi and Frederic Davi and Richard Rosenquist and Paolo Ghia and Kostas Stamatopoulos},
  journal={Blood},
  year={2012},
  volume={119 19},
  pages={4467-75}
}
Mounting evidence indicates that grouping of chronic lymphocytic leukemia (CLL) into distinct subsets with stereotyped BCRs is functionally and prognostically relevant. However, several issues need revisiting, including the criteria for identification of BCR stereotypy and its actual frequency as well as the identification of "CLL-biased" features in BCR Ig stereotypes. To this end, we examined 7596 Ig VH (IGHV-IGHD-IGHJ) sequences from 7424 CLL patients, 3 times the size of the largest… CONTINUE READING

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  • Immunol Today
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Highly Influential
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