Stereotactic radiosurgical treatment of brain metastases.


In a series of 33 patients with reasonably controlled primary cancers, stereotactic radiosurgery was used to treat 52 brain metastases. After a mean radiological follow-up time of 5.5 months, six lesions (12%) had stabilized in size, 26 (50%) were significantly reduced, and 15 (29%) had disappeared. One large melanoma metastasis progressed relentlessly despite treatment. Five lesions (9%) had decreased in size slightly before enlarging. In two of these lesions, biopsy revealed only necrosis. In almost all cases, treatment was associated with decreased peritumoral edema. However, a group of patients with large metastases and extensive prior brain irradiation has been identified in whom prolonged symptomatic cerebral edema poses a problem. It is concluded that radiosurgery is a viable alternative to surgical resection for some cases of brain metastasis.


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@article{Adler1992StereotacticRT, title={Stereotactic radiosurgical treatment of brain metastases.}, author={John R. Adler and Richard S. Cox and Irving D. Kaplan and D. Martin}, journal={Journal of neurosurgery}, year={1992}, volume={76 3}, pages={444-9} }