Stereotactic biopsy of an active multiple sclerosis lesion. Immunocytochemical analysis and neuropathologic correlation with magnetic resonance imaging.

@article{Estes1990StereotacticBO,
  title={Stereotactic biopsy of an active multiple sclerosis lesion. Immunocytochemical analysis and neuropathologic correlation with magnetic resonance imaging.},
  author={Melinda L. Estes and Richard A. Rudick and Gene H. Barnett and Richard M Ransohoff},
  journal={Archives of neurology},
  year={1990},
  volume={47 12},
  pages={1299-303}
}
Stereotactic biopsy of an active multiple sclerosis lesion in a 23-year-old patient with unilateral symptoms and an isolated high-signal-intensity magnetic resonance abnormality yielded 10 serial tissue cores (1.0 x 0.5 cm) spanning 40 mm within and around the lesion. We performed semiquantitative analysis of lymphocyte phenotype, using antisera to CD3, CD4, CD8, and CD22 molecules, in 11 separate perivascular cuffs in three tissue sections from the lesion edge. Total cells in the cuffs varied… CONTINUE READING

From This Paper

Topics from this paper.

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Neuropathologic correlates of magnetic resonance imaging in multiple sclerosis.

Journal of neuropathology and experimental neurology • 2012
View 1 Excerpt

Similar Papers

Loading similar papers…