Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.

@article{Gouda2005StereostructureOL,
  title={Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method.},
  author={Hiroaki Gouda and Toshiaki Sunazuka and Hideaki Ui and Masaki Handa and Yusuke Sakoh and Yuzuru Iwai and Shuichi Hirono and Satoshi Ōmura},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2005},
  volume={102 51},
  pages={
          18286-91
        }
}
  • H. Gouda, T. Sunazuka, +5 authors S. Ōmura
  • Published 2005
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
The absolute stereostructure of luminamicin, an anaerobic antibiotic, has been determined by using conformational analysis via high-temperature molecular dynamics, NMR spectroscopy, and the modified Mosher method. It was found that luminamicin has the S, S, R, R, R, R, S, S, S, R, and S configurations at C2, C4, C7, C9, C10, C11, C12, C13, C16, C28, and C29, respectively. This configuration is the same as that found in nodusmicin, which has a chemical structure quite similar to luminamicin. The… Expand
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