Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers

  title={Stereospecificity of the sensory irritation receptor for nonreactive chemicals illustrated by pinene enantiomers},
  author={Jukka-Pekka Kasanen and A L Pasanen and Pertti O Pasanen and Jyrki Liesivuori and Veli-Matti Kosma and Yves Alarie},
  journal={Archives of Toxicology},
To clarify the existence of a receptor protein for sensory irritants in trigeminal nerve endings, d- [i.e. (+)] and l- [i.e. (−)] enantiomers of α- and β-pinene as models of nonreactive chemicals were evaluated for their potency in outbred OF1 and NIH/S mice using ASTM E981-84 bioassay. All pinenes possess sensory irritation properties and also induced sedation and signs of anaesthesia but had no pulmonary irritation effects. According to the ratio of RD50 (i.e. concentration which causes a 50… CONTINUE READING
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