Stereospecific modulation of the calcium channel in human erythrocytes by cholesterol and its oxidized derivatives.

@article{Neyses1985StereospecificMO,
  title={Stereospecific modulation of the calcium channel in human erythrocytes by cholesterol and its oxidized derivatives.},
  author={Ludwig Neyses and Rudolf A. Locher and M. Stimpel and Rolf A Streuli and Wilhelm Vetter},
  journal={The Biochemical journal},
  year={1985},
  volume={227 1},
  pages={105-12}
}
To study the effect of cholesterol and its pathophysiologically important oxidized derivatives (OSC) on the calcium entry channel, the human red blood cell was used as a model system. The calcium ejecting adenosinetriphosphatase (ATPase) was inhibited by vanadate. The cells were loaded with OSC at concentrations between 1.25 X 10(-5) and 25 X 10(-5) mol/l. 22-Hydroxycholesterol, cholestan-3 beta,5 alpha,6 beta-triol, 5 alpha-cholestan-3 beta-ol,3 beta,5 alpha-dihydroxycholestan-6-one and 3 beta… CONTINUE READING
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