Stereospecific effects of d- and l-pentazocine on contractions of the mouse vas deferens.

@article{Kinouchi1986StereospecificEO,
  title={Stereospecific effects of d- and l-pentazocine on contractions of the mouse vas deferens.},
  author={Keiko Kinouchi and Kazuo Fukumitsu and Jun Takezawa and Sh{\^u}ichir{\^o} Maeda and Hiroshi Enomoto and J Kakuhari and Ikuto Yoshiya and Reizo Inoki},
  journal={Life sciences},
  year={1986},
  volume={39 2},
  pages={
          127-33
        }
}
  • Keiko Kinouchi, Kazuo Fukumitsu, +5 authors Reizo Inoki
  • Published 1986
  • Chemistry, Medicine
  • Life sciences
  • The effects of the d- and l-isomers of pentazocine were compared to that of racemic pentazocine on contractions of the mouse isolated vas deferens. L-pentazocine inhibited electrically evoked contractions of the mouse vas deferens (MVD) in a dose-dependent manner (ID50 0.37 +/- 0.04 microM). In contrast, d-pentazocine augmented field stimulated contractions dose-dependently; per cent increases in contractions at 10 and 30 microM were 57.8 +/- 18.0 and 98.0 +/- 15.1%, respectively. Racemic… CONTINUE READING

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