Stereospecific Synthesis of the Saccharosamine-Rhamnose-Fucose Fragment Present in Saccharomicin B.

@article{Bylsma2018StereospecificSO,
  title={Stereospecific Synthesis of the Saccharosamine-Rhamnose-Fucose Fragment Present in Saccharomicin B.},
  author={Marissa Bylsma and C. S. Bennett},
  journal={Organic letters},
  year={2018},
  volume={20 15},
  pages={
          4695-4698
        }
}
  • Marissa Bylsma, C. S. Bennett
  • Published 2018
  • Chemistry, Medicine
  • Organic letters
  • A synthetic route has been developed for constructing the d-saccharosamine-l-rhamnose-d-fucose (Sac-Rha-Fuc) trisaccharide fragment present in the antibacterial natural product saccharomicin B. The Sac monosaccharide was synthesized through a modified nine step procedure starting from d-rhamnal in 23% overall yield. 1- O-TBS Sac donors were used to construct the β-linked Sac-Rha disaccharide. This disaccharide was coupled to a Fuc acceptor under BSP/Tf2O conditions to afford a trisaccharide… CONTINUE READING
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