Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake Sites

Abstract

To investigate the stereoselective distribution of methylphenidate (MPD) enantiomers in rats, the concentrations of each enantiomer were determined in plasma and brain regions (cerebellum, striatum, basal forebrain, brain stem, and cortex) after iv administration of racemic MPD and its individual enantiomers. The concentrations of MPD enantiomers in each… (More)
DOI: 10.1023/A:1018917205292

Topics

Cite this paper

@article{Aoyama1994StereospecificDO, title={Stereospecific Distribution of Methylphenidate Enantiomers in Rat Brain: Specific Binding to Dopamine Reuptake Sites}, author={Takao Aoyama and Hajime Kotaki and Yasufumi Sawada and Tatsuji Iga}, journal={Pharmaceutical Research}, year={1994}, volume={11}, pages={407-411} }