Stereoselectivity of the benzannulation reaction: efficient central-to-axial chirality transfer.

Abstract

High diastereoselectivity is observed in the preparation of configurationally stable allocolchicinoids 5 from Fischer carbene complexes 4 and 1-pentyne. The analogous reaction of complexes 8 gives 9 with moderate diastereoselectivity for the opposite atropisomer and this selectivity can be taken to high levels under thermodynamic conditions.

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Cite this paper

@article{Vorogushin2002StereoselectivityOT, title={Stereoselectivity of the benzannulation reaction: efficient central-to-axial chirality transfer.}, author={Andrei V Vorogushin and William D Wulff and Hans-J{\"{u}rgen Hansen}, journal={Journal of the American Chemical Society}, year={2002}, volume={124 23}, pages={6512-3} }