Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation.

  title={Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation.},
  author={Elaine Lim{\'e} and Michelle D. Lundholm and A. Forbes and O. Wiest and P. Helquist and P. Norrby},
  journal={Journal of chemical theory and computation},
  volume={10 6},
  • Elaine Limé, Michelle D. Lundholm, +3 authors P. Norrby
  • Published 2014
  • Chemistry, Medicine
  • Journal of chemical theory and computation
  • The ruthenium-catalyzed asymmetric hydrogenation of simple ketones to generate enantiopure alcohols is an important process widely used in the fine chemical, pharmaceutical, fragrance, and flavor industries. Chiral diphosphine-RuCl2-1,2-diamine complexes are effective catalysts for the reaction giving high chemo- and enantioselectivity. However, no diphosphine-RuCl2-1,2-diamine complex has yet been discovered that is universal for all kinds of ketone substrates, and the ligands must be… CONTINUE READING
    17 Citations
    Stereoselectivity in (Acyloxy)borane-Catalyzed Mukaiyama Aldol Reactions.
    • 4
    Rapid virtual screening of enantioselective catalysts using CatVS
    • 11
    Prediction of Stereochemistry using Q2MM
    • 25
    Application of Q2MM to predictions in stereoselective synthesis.
    • 5
    • PDF
    Anomeric Effects in Sulfamides.
    • 8


    Mechanism of asymmetric hydrogenation of ketones catalyzed by BINAP/1,2-diamine-rutheniumII complexes.
    • 403
    • PDF