Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation.

@article{Lim2014StereoselectivityIA,
  title={Stereoselectivity in Asymmetric Catalysis: The Case of Ruthenium-Catalyzed Ketone Hydrogenation.},
  author={Elaine Lim{\'e} and Michelle D. Lundholm and A. Forbes and O. Wiest and P. Helquist and P. Norrby},
  journal={Journal of chemical theory and computation},
  year={2014},
  volume={10 6},
  pages={
          2427-35
        }
}
  • Elaine Limé, Michelle D. Lundholm, +3 authors P. Norrby
  • Published 2014
  • Chemistry, Medicine
  • Journal of chemical theory and computation
  • The ruthenium-catalyzed asymmetric hydrogenation of simple ketones to generate enantiopure alcohols is an important process widely used in the fine chemical, pharmaceutical, fragrance, and flavor industries. Chiral diphosphine-RuCl2-1,2-diamine complexes are effective catalysts for the reaction giving high chemo- and enantioselectivity. However, no diphosphine-RuCl2-1,2-diamine complex has yet been discovered that is universal for all kinds of ketone substrates, and the ligands must be… CONTINUE READING
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