Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin.

@article{Itoh1997StereoselectivityAE,
  title={Stereoselectivity and enantiomer-enantiomer interactions in the binding of ibuprofen to human serum albumin.},
  author={Tomoo Itoh and Y Saura and Yasuyuki Tsuda and Hideo Yamada},
  journal={Chirality},
  year={1997},
  volume={9 7},
  pages={643-9}
}
Binding of ibuprofen (IB) enantiomers to human serum albumin (HSA) was studied using a chiral fluorescent derivatizing reagent, which enabled the measurement of IB enantiomers at a concentration as low 5 x 10(-8) M. Scatchard analyses revealed that there were two classes of binding sites for both enantiomers. For the high affinity site, the number of the binding sites was one for both enantiomers, and the binding constant of R-IB was 2.3-fold greater than that of S-IB. The difference in the… CONTINUE READING