Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.

@article{Srinivas1992StereoselectiveUP,
  title={Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate and its major metabolite in humans.},
  author={Nuggehally R. Srinivas and John Waddington Hubbard and Elarien D. Korchinski and Kamal K. Midha},
  journal={Journal of pharmaceutical sciences},
  year={1992},
  volume={81 8},
  pages={
          747-9
        }
}
Stereoselective urinary pharmacokinetics of dl-threo-methylphenidate (MPH) and its major metabolite, dl-ritalinic acid (RA), were examined in a cohort of healthy subjects. On two occasions, separated by one week, each subject received MPH.HCl either intravenously (10 mg) or orally (40 mg). Urine was collected in six time segments, up to 16 h after each dosing. In the first 2 h after oral administration of MPH, d-MPH found in the urine was 10-fold greater than the l-antipode, whereas there was… CONTINUE READING

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