Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129.

@article{Mitsuya1999StereoselectiveSO,
  title={Stereoselective synthesis of a new muscarinic M3 receptor antagonist, J-104129.},
  author={Morihiro Mitsuya and Kumiko Kawakami and Yoshio Ogino and Keiko Miura and Toshiaki Mase},
  journal={Bioorganic \& medicinal chemistry letters},
  year={1999},
  volume={9 14},
  pages={
          2037-8
        }
}
Enantiospecific Synthesis of Penehyclidine Hydrochloride and Its Piperidine Derivatives with R Configuration
A novel and simple procedure for the enantiospecific synthesis of penehyclidine hydrochloride (8018) isomers and the R configuration derivatives was described. The intramolecular asymmetric
Synthesis and Crystal Structure of (9s)-N-methyl-3-azabicyclo[3.3.1] nonan-9-yl (cyclopentyl)(hydroxy)(2-thienyl)Acetate Hydrochloride
(9s)-N-methyl-3-azabicyclo[3.3.1]nonan-9-yl (cyclopentyl)(hydroxy)(2-thienyl)acetate hydrochloride, a more effective muscarinic receptor antagonist, was synthesised and its crystal structure
Optical Resolution, Stereoselective Synthesis, and Crystal Structure of 9α‐(3‐Azabicyclo[3,3,1]nonanyl)‐2′‐cyclopentyl‐2′‐hydroxy‐2′‐phenylacetate
Abstract 9α‐(3‐Azabicyclo[3,3,1]nonanyl)‐2′‐cyclopentyl‐2′‐hydroxy‐2′‐phenylacetate (1) was synthesized and its enantiomers were obtained by the optical resolution of racemates with the chiral host
Synthesis and Crystal Structure of 3-Quinuclidinyl α-(Cyclopentyl-1-ene)-α-hydroxy-α-phenylacetate
The title compound 3-quinuclidinyl α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetate was obtained by the reaction of methyl α-(cyclopentyl-1-ene)-α-hydroxy-α-phenylacetate with 3-quinuclidinol in
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Parasympatholytic (anticholinergic) esters of the isomeric 2-tropanols. 1. Glycolates.
TLDR
Several esters had significantly greater activity in both the peripheral and central nervous systems than did the reference compounds and were more potent than either its epimer (-)-2beta-tropanol or its optical isomer(-)-2alpha- Tropanol.