Stereoselective synthesis and osteogenic activity of subglutinols A and B.

@article{Kim2009StereoselectiveSA,
  title={Stereoselective synthesis and osteogenic activity of subglutinols A and B.},
  author={Hyoungsu Kim and Joseph B. Baker and Suui Lee and Yongho Park and Kyle L. Bolduc and Hyung-bae Park and Marina G. Dickens and Dong-Sup Lee and Yong‐Chul Kim and Seong Hwan Kim and Jiyong Hong},
  journal={Journal of the American Chemical Society},
  year={2009},
  volume={131 9},
  pages={
          3192-4
        }
}
Since clinically approved immunosuppressive drugs (e.g., cyclosporin A, FK506) possess dose-dependent biphasic effects that cause undesirable side effects on bone structure, including osteopenia, osteoporosis, and increased incidence of bone fractures, considerable effort has been devoted to the identification of immunosuppressive drugs that promote bone formation in a dose-dependent manner. Herein, we report the stereoselective synthesis of subglutinols A and B and present initial biological… 

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