Stereoselective pharmacokinetics of ketamine and norketamine after constant rate infusion of a subanesthetic dose of racemic ketamine or S-ketamine in Shetland ponies.

Abstract

OBJECTIVE To evaluate pharmacokinetics of ketamine and norketamine enantiomers after constant rate infusion (CRI) of a subanesthetic dose of racemic ketamine or S-ketamine in ponies. ANIMALS Five 6-year-old Shetland pony geldings that weighed between 101 and 152 kg. PROCEDURES In a crossover study, each pony received a CRI of racemic ketamine (loading… (More)
DOI: 10.2460/ajvr.70.7.831

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