Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding.

@article{Itoh1997StereoselectivePO,
  title={Stereoselective pharmacokinetics of ibuprofen in rats: effect of enantiomer-enantiomer interaction in plasma protein binding.},
  author={Tomoo Itoh and Jun-ich Maruyama and Yasuyuki Tsuda and Hideo Yamada},
  journal={Chirality},
  year={1997},
  volume={9 4},
  pages={354-61}
}
Stereoselective pharmacokinetics of ibuprofen (IB) enantiomers were studied in rats. Unidirectional conversion from R-ibuprofen (R-IB) to S-ibuprofen (S-IB) was observed following intravenous administration. S-IB concentrations in plasma following racemate administration were simulated according to a conventional compartmental model using the parameters obtained after the administration of individual enantiomers, and resulted in overestimation of S-IB concentrations. Binding of IB enantiomers… CONTINUE READING