Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.

@article{Gerber2004StereoselectiveMO,
  title={Stereoselective metabolism of methadone N-demethylation by cytochrome P4502B6 and 2C19.},
  author={John G. Gerber and Robert J Rhodes and Joseph Gal},
  journal={Chirality},
  year={2004},
  volume={16 1},
  pages={36-44}
}
Methadone is a clinically used opioid agonist that is oxidatively metabolized by cytochrome P450 (CYP) isoforms to a stable metabolite, EDDP. Methadone is a chiral drug administered as the racemic mixture of (R)-(-)- and (S)-(+)-methadone, but (R)-methadone is the active isomer. The cytochrome P450 (CYP) isoform involved in methadone's metabolism is thought to be CYP3A4, but human drug-drug interaction studies are not consistent with this. The ability of the common human drug-metabolizing CYPs… CONTINUE READING
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