Stereoselective isoxazolidine synthesis via copper-catalyzed alkene aminooxygenation.

Abstract

Isoxazolidines are useful in organic synthesis, drug discovery, and chemical biology endeavors. A new stereoselective synthesis of methyleneoxy-substituted isoxazolidines is disclosed. The method involves copper-catalyzed aminooxygenation/cyclization of N-sulfonyl-O-butenyl hydroxylamines in the presence of (2,2,6,6-tetramethylpiperidin-1-yl)oxyl radical… (More)
DOI: 10.1021/jo3013226

Topics

  • Presentations referencing similar topics