Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.

@article{Hasegawa2005StereoselectiveIO,
  title={Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor.},
  author={Michihiro Hasegawa and Atsuhiro Sugidachi and Taketoshi Ogawa and Takashi Isobe and Joseph A. Jakubowski and Fumitoshi Asai},
  journal={Thrombosis and haemostasis},
  year={2005},
  volume={94 3},
  pages={593-8}
}
CS-747 (Prasugrel, LY640315) is a thienopyridine antiplatelet prodrug that is metabolized to the thiol-containing active metabolite R-138727,which binds to and irreversibly inhibits the platelet P2Y12ADP receptor. R-138727 is composed of 4 stereo-isomers, (R, S)-, (R, R)-, (S, S)-, and (S, R)-isomers (the first letter for the configuration of a chiral center at the sulfur-bearing position and the second for that at the benzylic position). In the present study, we determined the… CONTINUE READING

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