Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.

@article{Hedman1998StereoselectiveIB,
  title={Stereoselective inhibition by the diastereomers quinidine and quinine of uptake of cardiac glycosides into isolated rat hepatocytes.},
  author={Ann Hedman and Dirk K. F. Meijer},
  journal={Journal of pharmaceutical sciences},
  year={1998},
  volume={87 4},
  pages={
          457-61
        }
}
  • A. HedmanD. Meijer
  • Published 1 April 1998
  • Biology, Medicine, Chemistry
  • Journal of pharmaceutical sciences
The pharmacokinetic interaction between quinidine and digoxin in patients is well-known, in general requiring a dose reduction of digoxin in patients concomitantly treated with quinidine. Quinine, the diastereomer of quinidine, has not been as extensively studied in this respect. In addition to an interaction with the renal clearance of digoxin by quinidine, both diastereomers have been reported to inhibit the biliary clearance of digoxin in man. To further investigate the mechanisms of these… 

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