Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.

@article{Madyastha2002StereoselectiveHO,
  title={Stereoselective hydroxylation of 4-methyl-2-cyclohexenone in rats: its relevance to R-(+)-pulegone-mediated hepatotoxicity.},
  author={K. M. Madyastha and C. P. Raj},
  journal={Biochemical and biophysical research communications},
  year={2002},
  volume={297 2},
  pages={
          202-5
        }
}
  • K. M. Madyastha, C. P. Raj
  • Published 2002
  • Chemistry, Medicine
  • Biochemical and biophysical research communications
  • R-(+)-Pulegone, a monoterpene ketone, is a potent hepatotoxin. One of the major metabolites of pulegone has been shown to be p-cresol, a glutathione depletor and a known toxin. Allylic hydroxylation of 4-methyl-2-cyclohexenone results in the formation of p-cresol. The present study documents for the first time the involvement of cytochrome P-450 system and the stereochemical preference in this hydroxylation reaction. Incubation of PB-induced rat liver microsomes as well as reconstituted PB… CONTINUE READING
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