Stereoselective glucuronidation of ornidazole in humans: predominant contribution of UDP-glucuronosyltransferases 1A9 and 2B7.

@article{Du2013StereoselectiveGO,
  title={Stereoselective glucuronidation of ornidazole in humans: predominant contribution of UDP-glucuronosyltransferases 1A9 and 2B7.},
  author={Jiangbo Du and Tiangeng You and Xiaoyan Chen and Da-fang Zhong},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2013},
  volume={41 7},
  pages={1306-18}
}
Ornidazole [R,S-1-chloro-3-(2-methyl-5-nitro-1H-imidazol-1-yl)propan-2-ol] is a chiral 5-nitroimidazole class antimicrobial agent. This study aimed to investigate the principal metabolic pathway of ornidazole in humans and identify the major enzymes involved. A total of 19 metabolites were identified in human urine collected from patients with hepatobiliary diseases after an intravenous drip infusion of 500 mg of racemic ornidazole. Stereoselective glucuronidation, followed by renal excretion… CONTINUE READING