Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.

@article{Wahl1992StereoselectiveEO,
  title={Stereoselective effects of AMOA on non-NMDA receptors expressed in Xenopus oocytes.},
  author={Philip Wahl and Birgitte Nielsen and Povl Krogsgaard-Larsen and Jan J. Hansen and Arne Schousboe and Ricardo Miledi},
  journal={Journal of neuroscience research},
  year={1992},
  volume={33 3},
  pages={392-7}
}
Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift to the right of the dose-response curve for kainate-induced currents. AMOA was found to have two different effects on AMPA receptors: 1) currents elicited by low concentrations of… CONTINUE READING