Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism.

@article{Dahl1994StereoselectiveDO,
  title={Stereoselective disposition of mianserin is related to debrisoquin hydroxylation polymorphism.},
  author={M L Dahl and Gunnel Tybring and C. E. Elwin and Christina Alm and Karin Andr{\'e}asson and M Gyllenpalm and Leif Bertilsson},
  journal={Clinical pharmacology and therapeutics},
  year={1994},
  volume={56 2},
  pages={176-83}
}
The pharmacokinetics of mianserin and its main metabolite desmethylmianserin were studied in poor and extensive metabolizers of debrisoquin and of S-mephenytoin after a single oral dose of racemic mianserin. The debrisoquin metabolic ratio (MR) correlated significantly with area under the serum concentration-time curves (AUC) for (+/-)-mianserin and (+/-)-desmethylmianserin. Enantioselective high-performance liquid chromatographic analysis of mianserin showed that debrisoquin MR was related to… CONTINUE READING

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