Stereoselective degradation of metalaxyl and its enantiomers in rat and rabbit hepatic microsomes in vitro.

@article{Zhang2012StereoselectiveDO,
  title={Stereoselective degradation of metalaxyl and its enantiomers in rat and rabbit hepatic microsomes in vitro.},
  author={Ping Zhang and Zhigang Shen and Xinyuan Xu and Wentao Zhu and Ziheng Dang and Xinru Wang and Donghui Liu and Zhiqiang Zhou},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2012},
  volume={42 6},
  pages={580-6}
}
The stereoselective degradations of racemate metalaxyl (rac-MX) and its single enantiomers in rat and rabbit hepatic microsomes were assayed by a chiral high-performance liquid chromatography method. The t(1/2) of (+)-S-MX in rat liver microsomes was between 7-8 min tested by rac-MX and the individual (+)-S-enantiomer, respectively, and that for (-)-R-MX was 15-16 min. In contrast, t(1/2) in rabbit liver microsomes was much longer and showed great difference when using racemate and single… CONTINUE READING

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