Stereoselective blockade of amphibian epithelial sodium channels by amiloride analogs.

Abstract

The blockade of amphibian epithelial sodium channels by amiloride has been shown to not be a simple diffusion-limited encounter but rather a selective binding process with the rate of approach of the molecule for the channel site determined by the side chain at position 2 of the pyrazine ring and the stability of the blocking complex provided largely by the… (More)

Topics

  • Presentations referencing similar topics