Stereoselective behavior of a novel biodegradable racemic ketoprofen injectable implant in rats.

Abstract

The stereoselectivity of release of ketoprofen (KET) enantiomers from a biodegradable injectable implant containing racemic KET (rac-KET) was investigated in vivo. A pre-column chiral derivatization RP-HPLC method was employed to assay diastereoisomeric derivatives of R- and S-KET. The rac-KET injectable implant, once injected subcutaneously in rats, produced long-lasting plasma levels of S-KET, which were always greater than those of R-KET. The difference in enantiomer concentration was to be related to stereoselective release, due to stereoselective interaction between D,L-PLG in the implant and KET enantiomers, as well as the chiral inversion of KET in vivo. The rac-KET injectable implant provided the sustained release of S-KET with effective plasma levels maintained for about 8 wk after a single injection.

Cite this paper

@article{Wang2007StereoselectiveBO, title={Stereoselective behavior of a novel biodegradable racemic ketoprofen injectable implant in rats.}, author={Sheng-Hao Wang and Li-na Yin and Ze-hua Liang and Si-jie Lu and Su Zeng}, journal={Chirality}, year={2007}, volume={19 10}, pages={769-74} }