Stereoselective analysis of hydroxybupropion and application to drug interaction studies.

@article{Xu2007StereoselectiveAO,
  title={Stereoselective analysis of hydroxybupropion and application to drug interaction studies.},
  author={Hongmei Xu and Katarzyna K Loboz and Annette S. Gross and Andrew J. McLachlan},
  journal={Chirality},
  year={2007},
  volume={19 3},
  pages={163-70}
}
A sensitive and stereoselective assay has been developed for the quantitation of the enantiomers of hydroxybupropion, an active metabolite of bupropion, in human plasma. The assay used liquid-liquid extraction and a Cyclobond I 2000 HPLC column with a mobile phase containing 3% acetonitrile, 0.5% triethylamine, and 20 mM ammonium acetate (pH 3.8). The technique was linear over the concentration range of 12.5-500 ng/ml for (2R,3R)- and (2S,3S)-hydroxybupropion. The method was reproducible as… CONTINUE READING

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