Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays

@article{Tan1998StereoselectiveSO,
  title={Stereoselective Synthesis of over Two Million Compounds Having Structural Features Both Reminiscent of Natural Products and Compatible with Miniaturized Cell-Based Assays},
  author={D. Tan and M. Foley and M. D. Shair and S. Schreiber},
  journal={Journal of the American Chemical Society},
  year={1998},
  volume={120},
  pages={8565-8566}
}
  • D. Tan, M. Foley, +1 author S. Schreiber
  • Published 1998
  • Chemistry
  • Journal of the American Chemical Society
  • Understanding the cellular function of a protein usually requires a means to alter the function. This is commonly done by mutating the gene encoding the protein (genetic approach). It can also be done by binding the protein directly with a small molecule ligand (chemical genetic approach). Such ligands, primarily natural products or synthetic variants of them, can either inactivate1 or activate2 protein function. For the chemical genetic approach to have its maximal impact, efficient methods of… CONTINUE READING
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