Stereoselective Synthesis of Piperidines by Iridium-Catalyzed Cyclocondensation.


An iridium-catalyzed cyclocondensation of amino alcohols and aldehydes is reported. Intramolecular allylic substitution by an enamine intermediate and subsequent in situ reduction furnishes 3,4-disubstituted piperidines with high enantiospecificity and good diastereoselectivity. The modular approach and the broad functional group tolerance provide access to… (More)
DOI: 10.1002/anie.201706374



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