Stereoselective Steady‐State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults

@article{Kharasch2020StereoselectiveSD,
  title={Stereoselective Steady‐State Disposition and Bioequivalence of Brand and Generic Bupropion in Adults},
  author={Evan D. Kharasch and Alicia Neiner and Kristin Kraus and Jane Blood and Angela Stevens and J. Philip Miller and Eric J. Lenze},
  journal={Clinical Pharmacology \& Therapeutics},
  year={2020},
  volume={108}
}
The antidepressant bupropion is stereoselectively metabolized and metabolite enantiomers have differential pharmacologic effects, but steady‐state enantiomeric disposition is unknown. Controversy persists about bupropion XL 300 mg generic equivalence to brand product, and whether generics might have different stereoselective disposition leading to enantiomeric non‐bioequivalence and, thus, clinical nonequivalence. This preplanned follow‐on analysis of a prospective, randomized, double‐blinded… 

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