Stereoselective Metabolism of the Monoterpene Carvone by Rat and Human Liver Microsomes

@article{Jger2000StereoselectiveMO,
  title={Stereoselective Metabolism of the Monoterpene Carvone by Rat and Human Liver Microsomes},
  author={Walter J{\"a}ger and Marion Mayer and Peter Platzer and Gottfried Reznicek and Hermann Dietrich and Gerhard Buchbauer},
  journal={Journal of Pharmacy and Pharmacology},
  year={2000},
  volume={52}
}
The large amounts of carvone enantiomers consumed as food additives and in dental formulations justifies the evaluation of their biotransformation pathway. The in‐vitro metabolism of R‐(—)‐ and S‐(+)‐carvone was studied in rat and human liver microsomes using chiral gas chromatography. 
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Plant-Derived Compounds as a Tool for the Control of Gastrointestinal Nematodes: Modulation of Abamectin Pharmacological Action by Carvone
TLDR
While ADMET (absorption, distribution, metabolism, excretion, and toxicity) predictions and the molecular docking study showed a good interaction between ABM and P-gp, R-CNE does not appear to modulate this efflux protein.
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