Stereological and immunohistochemical study of development of human fetal labial salivary glands and their S-100 protein reactivity.

Abstract

Stereological and certain histochemical aspects of fetal growth and development of human labial salivary glands are reported. Stereological analysis showed a highly significant progressive increase in proportional gland volume occupied by acini from 27% at 20 weeks to 56% at 38 weeks (P < 0.0001), and a comparable having of the relative gland volume occupied by connective tissue in the same period (P < 0.0001). Linear regression fitted the data well (r2 = 0.59 and 0.47 respectively, n = 46). The change in relative volume occupied by ducts or by vascular tissue was small and did not reach significance. S-100 protein reactivity was demonstrated in the cytoplasm of cells of the labial gland primordia from their origin. As gland differentiation progressed, the S-100 reactivity became localized in basophil acinar cells and in proximal (intercalated and intralobular), but not in distal, duct cells. A gradual increase in intensity of S-100 protein activity at these sites during salivary gland development was observed. Morphological maturity seems to be complete before 29 weeks but myoepithelial cells could not be identified with certainty.

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@article{Adi1994StereologicalAI, title={Stereological and immunohistochemical study of development of human fetal labial salivary glands and their S-100 protein reactivity.}, author={Mohamad Adi and Derrick M. Chisholm and Jenna Waterhouse}, journal={Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology}, year={1994}, volume={23 1}, pages={36-40} }