Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease.

@article{Hof2003StereologicEF,
  title={Stereologic evidence for persistence of viable neurons in layer II of the entorhinal cortex and the CA1 field in Alzheimer disease.},
  author={Patrick R. Hof and Thierry Bussi{\`e}re and Gabriel Gold and E K{\"o}vari and Panteleimon Giannakopoulos and Constantin Bouras and Daniel P. Perl and John Morrison},
  journal={Journal of neuropathology and experimental neurology},
  year={2003},
  volume={62 1},
  pages={55-67}
}
The entorhinal cortex and hippocampus are the first cortical regions to be affected by the degenerative cellular process that leads to Alzheimer disease (AD) and display a limited degree of neuronal alterations in normal aging. Several quantitative studies have reported a substantial loss of neurons in these regions and a parallel increase in the number of neurofibrillary tangles (NFTs). However, accurate quantitative data on the dynamics of NFT formation are lacking. Here, we performed a… CONTINUE READING
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