Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status.

@article{Bouras2006StereologicAO,
  title={Stereologic analysis of microvascular morphology in the elderly: Alzheimer disease pathology and cognitive status.},
  author={Constantin Bouras and E K{\"o}vari and François Herrmann and Claire-B{\'e}n{\'e}dicte Rivara and Thomasina L Bailey and Armin Von Gunten and Patrick R. Hof and Panteleimon Giannakopoulos},
  journal={Journal of neuropathology and experimental neurology},
  year={2006},
  volume={65 3},
  pages={235-44}
}
The presence of microvascular changes has been documented both in brain aging and Alzheimer disease (AD), although the relationship between the morphometry of brain capillaries and cognitive impairment is still unknown. We performed an analysis of capillary morphometric parameters and AD-related pathology in 19 elderly individuals with variable degrees of cognitive decline. Cognitive status was assessed prospectively using the Clinical Dementia Rating (CDR) scale. Total capillary lengths and… CONTINUE READING