Stereodivergent synthesis with a programmable molecular machine

@article{Kassem2017StereodivergentSW,
  title={Stereodivergent synthesis with a programmable molecular machine},
  author={Salma Kassem and Alan T. L. Lee and David A. Leigh and Vanesa Marcos and Leoni I Palmer and Simone Pisano},
  journal={Nature},
  year={2017},
  volume={549},
  pages={374-378}
}
It has been convincingly argued that molecular machines that manipulate individual atoms, or highly reactive clusters of atoms, with Ångström precision are unlikely to be realized. However, biological molecular machines routinely position rather less reactive substrates in order to direct chemical reaction sequences, from sequence-specific synthesis by the ribosome to polyketide synthases, where tethered molecules are passed from active site to active site in multi-enzyme complexes. Artificial… Expand
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