Stereodivergent hydrodefluorination of gem-difluoroalkenes: selective synthesis of (Z)- and (E)-monofluoroalkenes.

@article{Kojima2017StereodivergentHO,
  title={Stereodivergent hydrodefluorination of gem-difluoroalkenes: selective synthesis of (Z)- and (E)-monofluoroalkenes.},
  author={Ryoto Kojima and K. Kubota and Hajime Ito},
  journal={Chemical communications},
  year={2017},
  volume={53 77},
  pages={
          10688-10691
        }
}
We have developed a novel approach for the stereodivergent hydrodefluorination of gem-difluoroalkenes using copper(i) catalysts to obtain stereodefined monofluoroalkenes. Both (Z)- and (E)-terminal monofluoroalkenes were obtained by the hydrodefluorination of gem-difluoroalkenes in the presence of copper(i) catalysts and diboron or hydrosilane, respectively, with high stereoselectivity. DFT calculations were conducted to elucidate the stereoselectivity. 

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References

SHOWING 1-10 OF 46 REFERENCES
...
1
2
3
4
5
...