Stereocontrolled synthesis of oligoribonucleoside phosphorothioates by an oxazaphospholidine approach.

Abstract

Oligoribonucleoside phosphorothioates (PS-ORNs) stereodefined at the phosphorus atoms were synthesized on solid support. Thermal denaturating experiments of the resultant PS-ORNs showed that a backbone consisting of (Sp)-PS-linkages as well as stereorandom PS-linkages had an unexpectedly large destabilizing effect on a PS-ORN-ORN duplex, whereas a backbone… (More)
DOI: 10.1021/ol802910k

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