Stereocontrolled preparation of 1,2-diol with quaternary chiral center

@article{Murata2002StereocontrolledPO,
  title={Stereocontrolled preparation of 1,2-diol with quaternary chiral center},
  author={Yoshihisa Murata and T. Kamino and S. Hosokawa and Susumu Kobayashi},
  journal={Tetrahedron Letters},
  year={2002},
  volume={43},
  pages={8121-8123}
}
Development of an enantio- and stereoselective construction of 1,2-diols including a quaternary chiral center was achieved by a titanium-mediated aldol reaction of lactates bearing chiral oxazolidine-2-ones. anti-Aldol and syn-aldol were selectively obtained by the choice of a benzyl and TBS protecting group, respectively. Plausible transition states are also shown based on the stereochemistry of the enolate anion. 
23 Citations
Asymmetric tandem wittig rearrangement/Aldol reactions.
Addition To C=O Bonds III
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