Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes.

Abstract

The stereochemistry of the metabolism of vic-dihaloalkanes to alkenes has been studied. This glutathione-dependent biotransformation may occur by two mechanism. The first mechanism involves the nucleophilic attack of glutathione on the substrate resulting in S-(beta-haloalkyl)glutathione formation; subsequent attack of a second thiol on the sulfur atom of… (More)

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