Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes.


The stereochemistry of the metabolism of vic-dihaloalkanes to alkenes has been studied. This glutathione-dependent biotransformation may occur by two mechanism. The first mechanism involves the nucleophilic attack of glutathione on the substrate resulting in S-(beta-haloalkyl)glutathione formation; subsequent attack of a second thiol on the sulfur atom of… (More)


  • Presentations referencing similar topics