Stereochemistry: A source of problems in medicinal chemistry

@article{Arins1986StereochemistryAS,
  title={Stereochemistry: A source of problems in medicinal chemistry},
  author={E. J. Ari{\"e}ns},
  journal={Medicinal Research Reviews},
  year={1986},
  volume={6}
}
  • E. J. Ariëns
  • Published 1986
  • Chemistry, Medicine
  • Medicinal Research Reviews
Microspheres of biomolecules/macromolecules for enantioseparation applications
Abstract This review summarizes the recent advances in the enantioselective separation of small molecules using biomolecules/macromolecules built up by natural inherent chiral moieties. AlthoughExpand
Chirality-Dependent Growth of Self-Assembled Diphenylalanine Microtubes
The difference in the crystal structure and growth kinetics of microtubes formed from l- and d-enantiomers of diphenylalanine dipeptide is investigated both experimentally and theoretically byExpand
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A series of poly(biphenylylacetylene)s (PBPAs) bearing various functional groups at the 4′-position of the biphenyl pendants were synthesized. The effects of the pendant functional groups on theirExpand
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TLDR
This tutorial review shows that mechanical interactions do have significant effects on chiral objects at all scales, and can be induced using shearing surfaces, collisions with walls or repetitive microstructures, fluid flows, or by applying electrical or optical forces. Expand
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A rapid and efficient analytical method for the quantification of a novel anticholinergic compound, R-phencynonate, by stable isotope-dilution LC-MS/MS and its application to bioavailability and dose proportionality studies.
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The detailed pharmacokinetic profiles of R-phencynonate at therapeutic doses in rats and dogs were characterized by rapid oral absorption, quick clearance, high volume of distribution and poor absolute bioavailability. Expand
Chiral stationary phases consisting of π-conjugated polymers bearing glucose-linked biphenyl units: reversible switching of resolution abilities based on a coil-to-helix transition
A series of optically active π-conjugated polymers (poly-2–poly-5) consisting of alternating thieno[3,4-b]thiophene and glucose-linked biphenyl units were synthesized through copolymerizations byExpand
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