Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology

@article{Arins2004StereochemistryAB,
  title={Stereochemistry, a basis for sophisticated nonsense in pharmacokinetics and clinical pharmacology},
  author={E. J. Ari{\"e}ns},
  journal={European Journal of Clinical Pharmacology},
  year={2004},
  volume={26},
  pages={663-668}
}
  • E. J. Ariëns
  • Published 2004
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
SummaryThe significance of stereochemistry in therapeutic action is outlined and elucidated. Often only one isomer is therapeutically active, but this does not mean that the other is really inactive. It may very well contribute to the side-effects. The therapeutically non-active isomer in a racemate should be regarded as an impurity (50% or more). It is emphasized how in clinical pharmacology, and particularly in pharmacokinetics, neglect of stereoselectivity in action leads to the performance… Expand
Racemic Therapeutics—Problems all Along the Line
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Racemic therapeutics — ethical and regulatory aspects
  • E. J. Ariëns
  • Chemistry, Medicine
  • European Journal of Clinical Pharmacology
  • 2004
TLDR
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This review provides details of stereo-selectivity in the pharmacological behavior of some of β-blockers and their metabolites and highlights the distinction between the therapeutic behavior of the racemic mixtures and pure enantiomers. Expand
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  • Chemistry, Medicine
  • Annals of the New York Academy of Sciences
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