Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor

@article{Howlett1990StereochemicalEO,
  title={Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor},
  author={A. Howlett and T. Champion and G. Wilken and R. Mechoulam},
  journal={Neuropharmacology},
  year={1990},
  volume={29},
  pages={161-165}
}
  • A. Howlett, T. Champion, +1 author R. Mechoulam
  • Published 1990
  • Biology, Medicine
  • Neuropharmacology
  • The recent preparation of the enantiomers of 11-OH-delta 8-tetrahydrocannabinol-dimethylheptyl (THC-DMH), recrystallized to absolute enantiomeric purity, has made it possible to examine the requirement for stereospecificity for the interaction of this component with the cannabinoid receptor, defined by the binding of [3H]CP-55,940 and the adenylate cyclase enzyme. The enantiomer (-)11-OH-delta 8-THC-DMH exhibited a fully efficacious and potent (IC50 = 1.8 nM) inhibition of the accumulation of… CONTINUE READING
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